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American teenager Madison Keys overcame a left thigh injury to beat Venus Williams 6-3, 4-6, 6-4 at the Australian Open on Wednesday, ensuring there will be no Williams sisters semifinal.
The 19-year-old Keys will play Serena Williams in Thursday's semi-final after the world number one took out Dominika Cibulkova 6 2 6 2
The semifinalists from the other half of the women's draw have already been determined - No. 2 Maria Sharapova will play No. 10-seeded Ekaterina Makarova.
In men's quarter-final action - defending champion Stan Wawrinka beat 5th seed Kei Nishikori - who had upset him at the same stage at the US Open - 6-3 6-4 7-6.
Wawrinka showed a new willingness to rush forward and won 11 out of 13 points at the net, a potentially handy weapon in his arsenal for his Friday semi-final against world number one Novak Djokovic.
The Serb demolished Milos Raonic 7 6 6 4 6 2 in a shade over two hours.
Djokovic said his return of serve had been the key against the big hitting Canadian.
The first semi-final will be on Thursday night between Thomas Berdych, who beat Rafael Nadal in the last eight, and Andy Murray who accounted for Australia's last home hope Nick Kyrgios.