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Two people have been killed in a head-on-collision on the N2, about 5 km outside of Knysna, in the direction of Plettenberg Bay.
Police spokesperson, Capt Malcolm Pojie says a Toyota Quantam minibus collided head-on with a white VW Jetta on Friday morning.
He says a man and a woman in the Jetta died at the scene.
Pojie said 16 people in the minibus were injured.
The cause of the accident is not known.