Knysna Police have seized Mandrax tablets and tik worth more than 600-thousand and arrested two suspects - one from Port Elizabeth and one from Knysna.
Captain Malcolm Pojie of the Southern Cape Police says members of the Knysna Crime Prevention Unit made the bust on Wednesday night.
He said they followed up on information from the public and stopped a black Toyota Tazz with Eastern Cape registration plates near Hornlee.
A search ensued and the drugs were found hidden in the back door panels of the vehicle.
The haul included 4-thousand and 60 Mandrax tablets with an estimated street value of 264-thousand rand and ten parcels consisting of Tik and valued at 350-thousand rand.
The drugs and the vehicle were confiscated.
Captain Pojie says the suspects aged 28 and 29 were remanded in custody and will appear in the Knysna Magistrate's court on Friday on charges of dealing in drugs.