67 children with suspected food poisoning, were transported by ambulance from Chintsa to medical facilities in East London on Saturday afternoon.
Eastern Cape health departement spokesperson, Sizwe Kupelo says the children are all pupils at Byletts School.
He says the boarding school called the health department, when an abnormal number of children started suffering acute diarrhoea.
Kupelo says they were taken to Frere Hospital, Cecilia Makhwane Hospital and Gompo Community Health Centre in East London.
He says food poisoning is a problem at schools in remote areas of the province, where hygiene and proper food preparation procedures are sometimes neglected.
In recent months, there were three incidents where provincial health authorities had to fetch nearly 1000 children from rural villages - all with suspected food poisoning.