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Four boys between the ages of 14 and 17 tragically died in a hut in Willovale.
Police Spokesperson Captain Jackson Manatha says the boys, who were related, went to visit an initiate but he was not home at the time.
The victims decided to stay for the night when a fire broke out.
Police do not suspect any foul play and have opened in inquest docket.
Three people were killed in separate fires in informal settlements in Johannesburg.
Metro Spokesperson Robert Mulaudzi says the fires broke out in the early hours of Christmas day.
Disaster management officials have been activated to assist.
He appealed to communities to look after their heating and lighting appliances to avoid fires.
Meanwhile a man from Lenasia in Johannesburg burnt to death when his shack was set alight. Police say his door was deliberately blocked from the outside. A case of murder and arson was opened.