Police Spokesperson Captain Sandra Janse van Rensburg says the driver of a Toyota Starlet, was travelling on the N2 direction of Cape Town when he allegedly lost control of his vehicle.
She says the man, whose identity is still being withheld, collided with a Toyota Hilux that collided with a Mercedes truck.
The driver died on the scene while the driver and passenger of the Hilux Bakkie were transported to hospital.
Monday's fatal accident happened near the scene of a roadblock that was set up in the morning by traffic officials from the Nelson Mandela Bay Metro (NMB).
Motorists took to social media to air their frustrations, questioning the motives of the Metro to set up a roadblock on a National Road during peak hour traffic on a Monday morning.
Metro Traffic Chief Warren Prins told Algoa FM News that the roadblock formed part of Transport Month and will be the first of many in the Metro as they gear up for the festive season.
He says accusations on social media blaming the roadblock for the fatal accident were unfounded.
"The information from the public is absolutely wrong and fixated on creating a sensation. The roadblock was set out since 6h00 the morning on the N2 after the Cotswold Bridge with the necessary signage.
"The accident did happen on the same stretch of road but definitely not at the roadblock area. It happened way in front of the roadblock +- 700 to 800m where we were".
Prins added that the driver did not comply with the speed limit and was driving at excessive speed "waving" between vehicles when he realised the traffic was not moving.
He says they have had complaints about that stretch of road where several people have been killed or injured in accidents and decided to address the problem head-on.
Prins says they can have a roadblock wherever they want as long as the correct signage is placed on the road to alert motorists, which they have done.
He says the traffic on that part of the N2 already comes to a complete standstill during morning traffic, further defending their decision.
"People are always asking why they cannot see officials during peak hour traffic and if we then do show up it is also a problem"
Prins says they had great success during Monday's roadblock where 14 unroadworthy vehicles were impounded and 36 fines issued for taxi-related offences.
He says 51 unlicensed drivers and 55 unlicensed vehicles were stopped while 21 cars were pulled over, without number plates.
Fines were also issued for a total of 24 defective tyres.
When asked to comment on the growing problem of traffic lights being destroyed in vehicle accidents in the Metro, Prins had strong words.
"Those days are over, this is not a party city.
"He said going forward, the Metro will find those motorists responsible for destroying traffic lights, which cost the ratepayers between R100 000- R150 000 each.
Prins says even if you did not drive the vehicle, but it is registered in your name, you will be held responsible.