Eastern Cape police confiscated 38 pistols and five rifles from a group of people from a taxi organisation who gathered at the Nelson Mandela Hospital in Mthatha on Thursday.
Police spokesperson Colonel Priscilla Naidu says staff called the police after the group failed to adhere to the intervention by private security leaving staff and patients feeling intimidated.
She says the incident is related to the taxi violence that broke out earlier this week in Nqanqarhu (Formerly Maclear) and Mthatha.
Police searched the men and confiscated the 43 firearms.
They are investigating two murder and 12 attempted murder cases related to the taxi violence that broke out this week.
Last month, warring Eastern Cape taxi associations signed a "peace pact" which now seems to be under threat.