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The Sharks put their Super Rugby competition lead on the line against the red-hot Crusaders in Christchurch on Saturday where they have never won.
The men from Durban lead the competition by just one point from defending champions the Chiefs, with the Brumbies a further point away.
Jake White's team went down 16-9 to the Brumbies in Canberra last week, but face the seven-time Super Rugby champion Crusaders fuelled by the momentum of five straight wins.
A bonus-point victory could put the Crusaders level with the Sharks, while the Brumbies could go top if they beat the Cheetahs in Bloemfontein on Saturday.
The Chiefs, along with the Bulls and Auckland Blues, have byes this weekend.
The Western Force, in fifth spot overall and trailing the Brumbies by three points in the Australian conference, can celebrate their most successful campaign with a win over bottom-placed Stormers in Cape Town this weekend.