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Manchester United announced on their Twitter account on Monday that Manager David Moyes has left the club.
In a brief statement confirming his departure, Manchester United said it would like to place on record its thanks for the hard work, honesty and integrity he brought to the role.
News of Moyes's exit comes a day after widespread reports in the British media that he was facing the sack, just 10 months after succeeding Alex Ferguson as manager of the world-famous club.
On Easter Sunday, the Red Devils lost 2-0 to Moye's former club Everton at Goodison Park.
The 50-year-old Scot endured a torrid debut campaign at Old Trafford, with United falling to seventh place in the Premier League and being eliminated from both domestic cup competitions and the Champions League.
Current player-coach Ryan Giggs and his former United team-mate Nicky Butt are reportedly set to be placed in caretaker charge for Saturday's home game with Norwich City.
Louis van Gaal, the current Netherlands coach, has been installed as the favourite to succeed Moyes on a permanent basis by British bookmakers, with Jurgen Klopp of Borussia Dortmund another rumoured contender.