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Gqeberha police are investigating the murder of a young man who was shot in a house in Helenvale on Friday morning.
Captain Andre' Beetge, said four other people, three women and a man, were all shot in their legs.
He said five suspects were involved in the attack on the house in Elk Street, where a 20-year-old male who was wounded in the head.
He died later in hospital.
Beetge said the police's anti-gang unit is investigating a case of murder and four cases of attempted murder.
Anyone who may know the whereabouts of the gunmen should contact the investigating officer, Detective Warrant Officer Phillips at 082 387 6765 or alternatively Crime Stop at 08600 10111.