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A 53-year-old man from Malabar in Gqeberha is in police custody following his arrest for illegally possessing medicine.
Spokesperson Colonel Priscilla Naidu says police received a tip-off and pounced on two homes in Malabar on Tuesday.
She says a multi-disciplinary team was involved in the operation, resulting in the seizure of illicit cigarettes and Schedule 5 and 6 medicine.
Colonel Naidu says the 45 cases of illicit cigarettes have an estimated value of R540 000 while the medicine is estimated at R2.6 million.
She says the suspect was arrested in one of the two homes and will be charged with contravening the Medicines Control Act.
The suspect is expected to appear in court soon.
