At least four people, including a child, were killed, and two injured following a head-on collision on the N-2, about 5km's outside Mthatha on Monday morning.
Provincial traffic spokesperson, Charles Bramwell says the accident between two cars happened just before 7 o'clock.
The victims were two female passengers, the driver and a child.
The bodies have been removed from the wreckage.
Two people were seriously injured and taken to a hospital.