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King Williams Town Cluster Police arrested 110 suspects in a Festive Season Operation that started on Friday evening and ended on Tuesday.
The suspects are aged 20 to 62 and are all from the King Williams Town area.
The suspects were arrested for a range of crimes - including murder, robbery, assault and possession of dagga
Police Lieutenant Siphokazi Mawisa says a 40-year-old man was arrested for the murder of a 48 year-old man, who was stabbed to death in Ohlson location at Stutterheim.
Meanwhile: East London police have arrested 37 people during a crime prevention operation at Duncan Village.
Captain Stephen Marais says most of the arrests were for drunken and disorderly behaviour.
He says a number of suspects were arrested for more serious crimes including murder, assault, theft and possession of dagga.
Port Alfred Cluster police arrested 60 suspects this past long weekend, including a 34-year-old man for allegedly raping a 32-month-old baby in Nemato Township.