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US President Barack Obama will hold talks this morning with president Jacob Zuma at the Union Buildings.
The two leaders are expected to discuss a range of issues aimed at cementing bilateral relations between the two countries.
Trade and Industry Minister, Rob Davies, said this week that South Africa will be lobbying for a 15 to 20 year extension of the US's African Growth and Opportunity Act - Agoa.
Davies says he believes that the act, which grants duty free access of specific products from Africa into the US market, had contributed significantly to the balance of the bilateral trade between South Africa and the US, which in 2012 amounted to R122.7bn.
Obama landed at the Waterkloof airbase in Pretoria last night accompanied by his wife Michelle and daughters Malia and Sasha.
He was greeted by a guard of honour on his first visit to South Africa as president and the second leg of his three nation African tour.
The two presidents are scheduled to address the media at noon on Saturday.
Meanwhile, a protest is being planned against Obama when he addresses students at the University of Johannesburg on Saturday afternoon.
A group calling itself the No You Cant Obama Campaign, accuses the US president of escalating the assault on human rights, the militarisation of international relations and continuing guzzling of world resources at the expense of the environment and oppressed peoples of the world.
The NOBAMA campaign groups include trade unions under Cosatu, the Friends of Cuba Society and the SA Muslims Students Association among a host of others.