Defending champions Chelsea were stunned 2-1 by Shakhtar Donetsk in a Champions League group E match in the Ukraine on Tuesday night.
Alex Teixeira gave the home side the best-possible start with a goal in the third minute and Fernandinho added the second on 52 minutes.
Oscar pulled one back for the visitors with just two minutes remaining, but it was a case of too little too late.
In the other group game Danish Champions League rookies FC Nordsjaelland conceded a late goal to draw one-all with mighty Juventus.
In Group G Jordi Alba scored in the third minute of extra time to secure a 2-1 win at home for Barcelona against Celtic.
Manchester United had to come back from two goals down to beat Sporting Braga 3-2 in group H.
The win sees United top the group with nine points.