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Five-time champion Roger Federer was knocked out in the quarter finals of the U.S. Open on Wednesday night by Tomas Berdych, with the Czech completing a 7-6 6-4, 3-6, 6-3 victory.
It is the first time since 2003 that Federer has not reached the semifinals at Flushing Meadows as he struggled with a wayward forehand.
Berdych will now face British third seed Andy Murray after the Scot beat Croatia's Marin Cilic 3-6, 7-6 (7/4), 6-2, 6-0.
In fourth round matches, Janko Tipsarevic beat Philipp Kolschreiber and Stanislas Warwrinka retired in the third set of his match against Novak Djokovic.
Juan Martin Del Potro sent Andy Roddick into retirement with a 6 7 7 6 6 2 6 4 victory.
In ladies play: US fourth seed Serena Williams advanced to the US Open semi-finals for the fourth time in five years by beating Serbian 12th seed Ana Ivanovic 6-1, 6-3 in 58 minutes.
In Friday's semi-finals, Serena will play the Italian 10th seed Sara Errani who beat her countrywoman Roberta Vinci in straight sets.
Maria Sharapova beat Marion Bartoli 3 6 6 3 and 6 4 and will play world number one Victoria Azarenka in the other semi-final.
