Manchester United and arch-rivals Manchest City were outplayed and comprehensively beaten in the Europa League on Thursday night.
United lost 3-2 at home to a fearless and skilful Athletic Bilbao, their second successive European defeat at Old Trafford, in the first leg of their round-of-16 tie.
Central defender Xandao scored with a cheeky back-heel to give Sporting a 1-0 win over City in Lisbon, ending the Premier League leaders' run of six straight wins.
Valencia, 4-2 winners over PSV Eindhoven at home, and Atletico Madrid, who beat Besiktas 3-1, completed an excellent night for Spanish clubs.