Tik with an estimated street value of R6.7 million was seized at OR Tambo International Airport.
The SA Revenue Service says 22.6kg of the drug was found in possession of a woman arriving in Johannesburg from Dubai on Monday.
SARS spokesperson Marika Muller says the woman was identified for further checks and denied having any luggage.
However, her ticket however indicated that she had checked in luggage.
Airport staff found the luggage and handed it to SARS, and a sniffer dog reacted positively when led to her luggage.