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A farm in Worcester in the Western Cape is the latest broiler breeder farm to test positive for avian flu.
Two farms in Gauteng have been under quarantine since early April.
There is currently no vaccine or treatment for this highly pathogenic avian influenza which is why thousands of birds had to be culled.
The Western Cape Government says the affected farm is under quarantine, and the process of humanely culling the affected chickens is underway.
This strain of avian influenza is carried by wild birds, especially at this time of year when their natural migration northwards occur.
Botswana and Mozambique have already banned all poultry meat, eggs and feathers from SA, while Lesotho has banned the import of eggs from Gauteng.
Namibia has banned all products from the affected areas.
Consumers are ensured that eggs and broiler meat products are safe to eat provided normal cooking protocols are followed.